Image Registration of binary images

HI guys, I’d like to register two binary brain images. I tried to use the MSE, correlation and MI in the SimpleITK but the result was not so good, so what metric do you suggest? I think that I need a metric which compares binary images, but what? And is It possible to add a new metric for the registration process in the SimpleITK?


Similarity metric for binary images and label maps is called Match Cardinality in ITK. You could use that, or compute signed distance field of both images and register SDFs using MSE.