How to pick filters available in ITK for 3D medical image segmentation

Hi All,

I was going over filters available in itk to develop and implement segmentation algorithm for a 3D CT scan image. There are so many filters to pick and choose for each stages of segmentation. Is there guidance on how to choose particular filters for solving segmentation problem of 3D medical images ? Any particular key points to keep in perspective while making decisions on choosing the filters ?