I am looking at registration of whole-body CT image volumes, repeat scans of the same individual over several month span. My primary concern is efficiency, secondary concern is accuracy and so I am tuning carefully to makes sure the registration workflow is fast. Not surprisingly, I am having a really hard time tuning the registration (just rigid transformation) to consistently converge on a reasonable solution.
These images contain a lot of air outside of the body and I am concerned that the alignment of air regions creates a lot of local minima in the parameter space in which the optimizer is getting stuck.
I am curious about whether imposing limits of the point sample space to more closely align with the limits of the body contour will help constrain the optimization. Is there ITK API that supports setting limits on the sampling point set domain that is used to determine the similarity metric (Mattes MI) at each iteration? If not I suppose I could also trim the image volume prior to registration, but the former seems like a nicer option to me.
Any feedback/discussion would be much appreciated.