ITK Snap Registration - Background turns white with rotation or translation

Hello there! I’m using ITK Snap to reorient the translation & rotation of a set of MRI images with the manual registration tool. Everything has been working well until recently when I had an image background change from black to white outside. Then when I reslice and save the oriented image it is saved as a 16bit signed image instead of unsigned. Changing from signed to unsigned is simple enough, but the issue is that I now have these white regions in the corners of the image. The issue seems to be isolated just to this one image. Looking at the header, nothing seems different about the original file compared to any others. Any ideas on how I can fix this?

Example Files:

Thank you so much!

This is more of a question for ITK-SNAP users mailing list.

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