I am again encountering problems working with a tiff > 2GB. (I inquired about a similar problem previously, and three of my posts were removed for being ads or promotional - it doesn’t make any sense to me.)
I have used ITK to create a 3D tiff (from 400 slices) that is a bit bigger than 2GB. It is not recognized by irfanview-64 or by Fiji. If I reduced the number of slices to 350 everything is OK. I don’t understand where the 2GB restriction is coming from. I thought maybe it was a Windows issue, but in that case surely I would not be able to create the tiff to start with.