# Problem when opening a big TIF file

**URL:** https://discourse.itk.org/t/problem-when-opening-a-big-tif-file/4858
**Category:** Beginner Questions
**Created:** [March 11, 2022, 11:38am UTC](https://discourse.itk.org/t/problem-when-opening-a-big-tif-file/4858 "2022-03-11T11:38:48Z")
**Posts on this page:** 1
**Page:** 1

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### Author: ![Jeremie](https://discourse.itk.org/letter_avatar_proxy/v4/letter/j/e47c2d/32.png) [@Jeremie](https://discourse.itk.org/u/Jeremie)
#### Post date: [March 11, 2022, 11:38am UTC](https://discourse.itk.org/t/problem-when-opening-a-big-tif-file/4858/1 "2022-03-11T11:38:48Z")

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Hello,

I am doing mouse brains alignement to the Allen Brain Atlas. Samples are optically cleared and images are obtained on a light sheet microscope. I use ITK Elastix for registration.

It works nicely on small files (25x25x25 um voxel : 100 Mo in size).

However, when I am trying to apply the transformation to a high resolution data set of 70 Go, I have a problem: I cannot open the file at all:

- when trying to change the voxel spacing, it works on small size file but not on the big one.

If I crop the big one, it is opened correctly… That makes me think that the data type is good, but that it is some sort of memory problem.

I am working on Windows 10, with 512 Go Ram.

Is there an image size limit?

Thank you very much for your help!!

Best,

Jérémie