# Normalized mutual information combined with gradient descent as a similarity measure function for 2D/3D registration

**URL:** https://discourse.itk.org/t/normalized-mutual-information-combined-with-gradient-descent-as-a-similarity-measure-function-for-2d-3d-registration/5351
**Category:** Uncategorized
**Created:** [September 21, 2022, 12:00pm UTC](https://discourse.itk.org/t/normalized-mutual-information-combined-with-gradient-descent-as-a-similarity-measure-function-for-2d-3d-registration/5351 "2022-09-21T12:00:18Z")
**Posts on this page:** 1
**Page:** 1

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### Author: ![12qew](https://discourse.itk.org/user_avatar/discourse.itk.org/12qew/32/2946_2.png) [@12qew](https://discourse.itk.org/u/12qew)
#### Post date: [September 21, 2022, 12:00pm UTC](https://discourse.itk.org/t/normalized-mutual-information-combined-with-gradient-descent-as-a-similarity-measure-function-for-2d-3d-registration/5351/1 "2022-09-21T12:00:18Z")

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Hello everyone, I have been working on 2D/3D registration recently and encountered a problem. In this project of mine, the sum function of normalized mutual information and gradient descent is used as the similarity measure function to measure registration. I would like to ask you, if there is any reference code, case, or idea you can provide, thank you very much.