# Is there a skull stripping module in SimpleITK that can work with MultiVolume?

**URL:** <https://discourse.itk.org/t/is-there-a-skull-stripping-module-in-simpleitk-that-can-work-with-multivolume/4519>\
**Category:** Algorithms\
**Created:** [October 23, 2021, 7:37pm UTC](https://discourse.itk.org/t/is-there-a-skull-stripping-module-in-simpleitk-that-can-work-with-multivolume/4519 "2021-10-23T19:37:08Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![kliron](https://discourse.itk.org/letter_avatar_proxy/v4/letter/k/c6cbf5/32.png) [@kliron](https://discourse.itk.org/u/kliron)\
**Post date:** [October 23, 2021, 7:37pm UTC](https://discourse.itk.org/t/is-there-a-skull-stripping-module-in-simpleitk-that-can-work-with-multivolume/4519/1 "2021-10-23T19:37:08Z")

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I need to do brain extraction from a number of MRI time series (DSC perfusion data). I found [this](https://github.com/InsightSoftwareConsortium/ITKSkullStrip) itk module which, unless I am missing something doesn’t seem to support 4D sequences. I can load my DICOM files as a time-indexed list of 3D volumes and process each one sequentially. I am unsure how I combine these multiple 3D Volumes into a single MultiVolume (which hopefully I can save as a .nrrd file or similar).

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**Author:** ![zivy](https://discourse.itk.org/user_avatar/discourse.itk.org/zivy/32/1726_2.png) [@zivy](https://discourse.itk.org/u/zivy)\
**Post date:** [October 23, 2021, 11:36pm UTC](https://discourse.itk.org/t/is-there-a-skull-stripping-module-in-simpleitk-that-can-work-with-multivolume/4519/2 "2021-10-23T23:36:46Z")

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[JoinSeriesImageFilter](https://simpleitk.org/doxygen/latest/html/classitk_1_1simple_1_1JoinSeriesImageFilter.html)

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**Author:** ![kliron](https://discourse.itk.org/letter_avatar_proxy/v4/letter/k/c6cbf5/32.png) [@kliron](https://discourse.itk.org/u/kliron)\
**Post date:** [October 24, 2021, 6:14am UTC](https://discourse.itk.org/t/is-there-a-skull-stripping-module-in-simpleitk-that-can-work-with-multivolume/4519/3 "2021-10-24T06:14:47Z")

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Awesome, thanks. Sorry, I should have looked at the available filters list before posting a question 🙄