# Latest

**URL:** https://discourse.itk.org/latest.md?page=2

[Latest](https://discourse.itk.org/latest.md) · [Categories](https://discourse.itk.org/categories.md) · [Tags](https://discourse.itk.org/tags.md)

**Page:** 3

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## [X-ray image file of TIFF format proces](https://discourse.itk.org/t/x-ray-image-file-of-tiff-format-proces/7693)

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**Author:** [@wulicheng](https://discourse.itk.org/u/wulicheng)\
**Replies:** 0\
**Last updated:** [January 6, 2026, 6:08am UTC](https://discourse.itk.org/t/x-ray-image-file-of-tiff-format-proces/7693 "2026-01-06T06:08:25Z")

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I have a large x-ray file of TIFF in the link. I want to process it more clarity. Expecially the link line in the image . I have do something. But it is not enough。 Will you give me some sugesstions. Thinks! This is the…

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## [Query on Regularization with BSplineTransform and GradientDescent in SimpleITK](https://discourse.itk.org/t/query-on-regularization-with-bsplinetransform-and-gradientdescent-in-simpleitk/7690)

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**Author:** [@blue\_sky](https://discourse.itk.org/u/blue_sky)\
**Replies:** 4\
**Last updated:** [January 5, 2026, 4:17pm UTC](https://discourse.itk.org/t/query-on-regularization-with-bsplinetransform-and-gradientdescent-in-simpleitk/7690 "2026-01-05T16:17:06Z")

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Hello everyone, I am currently working with SimpleITK for image registration, specifically employing sitk.BSplineTransform and the SetOptimizerAsGradientDescent optimizer. I’ve been reviewing a Python example that demo…

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## [Different Rotation Matrices between Euler3DTransform and Scipy Rotation](https://discourse.itk.org/t/different-rotation-matrices-between-euler3dtransform-and-scipy-rotation/4273)

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**Author:** [@Floowey](https://discourse.itk.org/u/Floowey)\
**Replies:** 6\
**Last updated:** [December 25, 2025, 7:20am UTC](https://discourse.itk.org/t/different-rotation-matrices-between-euler3dtransform-and-scipy-rotation/4273 "2025-12-25T07:20:45Z")

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Hello, I’m trying to rotate sections of my images according to certain orientations. However, I noticed some discrepancies between the rotations of the Euler3DTransform object and scipy.spatial.transform.Rotation when g…

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## [CMakelists.txt file question](https://discourse.itk.org/t/cmakelists-txt-file-question/7685)

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**Author:** [@ogdenk](https://discourse.itk.org/u/ogdenk)\
**Replies:** 7\
**Last updated:** [December 23, 2025, 9:09pm UTC](https://discourse.itk.org/t/cmakelists-txt-file-question/7685 "2025-12-23T21:09:06Z")

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Hi all. I am a casual user of ITK, and haven’t used it in a few years. When I recently set it up again, I found that the original CMakelists.txt file I had previously used didn’t work any more in CMake. This is a smal…

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## [Compilation failed: ITKDeprecatedTestDriver.exe](https://discourse.itk.org/t/compilation-failed-itkdeprecatedtestdriver-exe/7681)

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**Author:** [@Rosie](https://discourse.itk.org/u/Rosie)\
**Replies:** 7\
**Last updated:** [December 19, 2025, 1:22am UTC](https://discourse.itk.org/t/compilation-failed-itkdeprecatedtestdriver-exe/7681 "2025-12-19T01:22:37Z")

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Dear developer, It is failed when I try to compile the test driver of ITKDeprecated module. The error message is as follows. C:\\ITK\\Modules\\Compatibility\\Deprecated\\include\\itkTreeIteratorBase.hxx(238,30): error C2039:…

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## [Error MSB8066 during building?](https://discourse.itk.org/t/error-msb8066-during-building/7671)

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**Author:** [@Rock](https://discourse.itk.org/u/Rock)\
**Replies:** 7\
**Last updated:** [December 18, 2025, 6:48pm UTC](https://discourse.itk.org/t/error-msb8066-during-building/7671 "2025-12-18T18:48:15Z")

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Hello all, I have been trying to get SimpleITK set up with Elastix, following the instructions on the pages for Building SimpleITK and Building SimpleITK on Windows. I am using Visual Studio 18, Python 3.14, and CMake 4…

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## [Reading/casting .tif images into SimpleITK](https://discourse.itk.org/t/reading-casting-tif-images-into-simpleitk/7683)

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**Author:** [@Rock](https://discourse.itk.org/u/Rock)\
**Replies:** 1\
**Last updated:** [December 18, 2025, 5:53pm UTC](https://discourse.itk.org/t/reading-casting-tif-images-into-simpleitk/7683 "2025-12-18T17:53:52Z")

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Hello, My lab has .tif images we need to do a groupwise registration on and I am having difficulty reading them into SimpleITK. If I understand correctly, to register images they need to be floats so I have tried readin…

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## [QVTKNativeWidget: Jagged edges on 2D images](https://discourse.itk.org/t/qvtknativewidget-jagged-edges-on-2d-images/7682)

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**Author:** [@Manjunath\_AV](https://discourse.itk.org/u/Manjunath_AV)\
**Replies:** 1\
**Last updated:** [December 17, 2025, 5:53pm UTC](https://discourse.itk.org/t/qvtknativewidget-jagged-edges-on-2d-images/7682 "2025-12-17T17:53:00Z")

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Hi all, I’m displaying 2D images using QVTKNativeWidget and I’m seeing zigzag/jagged edges along high-contrast boundaries. I’ve attached two screenshots: Current issue: edges look stair-stepped/pixelate image670×2…

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## [What happened to the Insight Journal?](https://discourse.itk.org/t/what-happened-to-the-insight-journal/7679)

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**Author:** [@gdevenyi](https://discourse.itk.org/u/gdevenyi)\
**Replies:** 3\
**Last updated:** [December 16, 2025, 8:33pm UTC](https://discourse.itk.org/t/what-happened-to-the-insight-journal/7679 "2025-12-16T20:33:14Z")

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For many articles, I can’t access the PDF, for others, the source and data, and for others, the article page is completely missing, even though it does show up in a search. (I’ve opened issues for all of this). Is there…

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## [Tuning Optimizer(s) for almost-aligned images](https://discourse.itk.org/t/tuning-optimizer-s-for-almost-aligned-images/7676)

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**Author:** [@gdevenyi](https://discourse.itk.org/u/gdevenyi)\
**Replies:** 12\
**Last updated:** [December 16, 2025, 1:55pm UTC](https://discourse.itk.org/t/tuning-optimizer-s-for-almost-aligned-images/7676 "2025-12-16T13:55:42Z")

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Hi all, I’m trying to understand how to tune the optimizer for aligning almost-aligned images, in this case adjacent frames in a time-series. I’m having a terrible time tuning the optimizer learning rates and estimates…

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## [What is the default center of rotation for an Euler3DTransform?](https://discourse.itk.org/t/what-is-the-default-center-of-rotation-for-an-euler3dtransform/7677)

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**Author:** [@gdevenyi](https://discourse.itk.org/u/gdevenyi)\
**Replies:** 2\
**Last updated:** [December 7, 2025, 4:33pm UTC](https://discourse.itk.org/t/what-is-the-default-center-of-rotation-for-an-euler3dtransform/7677 "2025-12-07T16:33:24Z")

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If i do not use a transform initializer for a registration, what will be the center of rotation?

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## [ITK/RTK config and build to use CudaBackProjectionImageFilter python wrapper](https://discourse.itk.org/t/itk-rtk-config-and-build-to-use-cudabackprojectionimagefilter-python-wrapper/7658)

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**Author:** [@jshenNT](https://discourse.itk.org/u/jshenNT)\
**Replies:** 9\
**Last updated:** [December 4, 2025, 4:49pm UTC](https://discourse.itk.org/t/itk-rtk-config-and-build-to-use-cudabackprojectionimagefilter-python-wrapper/7658 "2025-12-04T16:49:00Z")

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Hello, I’m new to ITK/RTK and currently working on a project where we want to use RTK’s reconstruction functionality, specifically CudaFDKBackProjectionImageFilter. However, due to my limited experience with ITK/RTK, I…

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## [Running optimizer in parallel](https://discourse.itk.org/t/running-optimizer-in-parallel/1421)

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**Author:** [@Gordian](https://discourse.itk.org/u/Gordian)\
**Replies:** 6\
**Last updated:** [December 3, 2025, 8:42pm UTC](https://discourse.itk.org/t/running-optimizer-in-parallel/1421 "2025-12-03T20:42:34Z")

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Hello, i have a question regarding parallel optimization. The actual setup is more cpmplex. Therefore I try to simplify. I have a reference image and multiple other images. I want to register the other images onto the …

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## [Error building ITK 5.4 with CMake on MSVC 19.44: unresolved external symbol \_\_std\_find\_first\_of\_trivial\_pos\_1](https://discourse.itk.org/t/error-building-itk-5-4-with-cmake-on-msvc-19-44-unresolved-external-symbol-std-find-first-of-trivial-pos-1/7673)

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**Author:** [@thanhst](https://discourse.itk.org/u/thanhst)\
**Replies:** 7\
**Last updated:** [December 1, 2025, 2:02am UTC](https://discourse.itk.org/t/error-building-itk-5-4-with-cmake-on-msvc-19-44-unresolved-external-symbol-std-find-first-of-trivial-pos-1/7673 "2025-12-01T02:02:21Z")

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Hi ITK team, I built ITK 5.4 using CMake and Visual Studio 2022. Everything compiles and links fine for most headers, but when I include \<itkImageFileReader.h\> in my project, I get the following linker error with file i…

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## [ITK 5.4.5 has been released! Onboarding AI Agents](https://discourse.itk.org/t/itk-5-4-5-has-been-released-onboarding-ai-agents/7670)

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**Author:** [@matt.mccormick](https://discourse.itk.org/u/matt.mccormick)\
**Replies:** 0\
**Last updated:** [November 24, 2025, 9:00pm UTC](https://discourse.itk.org/t/itk-5-4-5-has-been-released-onboarding-ai-agents/7670 "2025-11-24T21:00:32Z")

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We are pleased to announce the release of ITK 5.4.5! ITK 5.4.5 is a maintenance release focused on critical bug fixes, improved documentation, and platform support, while introducing AI agent onboarding to assist in pro…

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## [ITK-SNAP 4.4.0 – “Access Denied” Error During Local Server Python Package Setup](https://discourse.itk.org/t/itk-snap-4-4-0-access-denied-error-during-local-server-python-package-setup/7668)

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**Author:** [@Pranathi\_Induri](https://discourse.itk.org/u/Pranathi_Induri)\
**Replies:** 1\
**Last updated:** [November 21, 2025, 5:35pm UTC](https://discourse.itk.org/t/itk-snap-4-4-0-access-denied-error-during-local-server-python-package-setup/7668 "2025-11-21T17:35:49Z")

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Hi everyone, I faced an issue while setting up the Local Server in ITK-SNAP 4.4. When I clicked “Setup Python Packages”, the installation failed with an “Access denied” error related to files inside the auto-created dls…

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## [Correlation value from ITK Montage](https://discourse.itk.org/t/correlation-value-from-itk-montage/7666)

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**Author:** [@rhysgt](https://discourse.itk.org/u/rhysgt)\
**Replies:** 1\
**Last updated:** [November 18, 2025, 7:58pm UTC](https://discourse.itk.org/t/correlation-value-from-itk-montage/7666 "2025-11-18T19:58:40Z")

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Is there any way to access correlation value for each tile pair from a TileMontage object? Ultimately, I would like to show these visually for the overlapped region between each neighbouring tile pair so that I can easil…

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## [Patches fro ITK 5.4.5](https://discourse.itk.org/t/patches-fro-itk-5-4-5/7656)

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**Author:** [@matt.mccormick](https://discourse.itk.org/u/matt.mccormick)\
**Replies:** 6\
**Last updated:** [November 18, 2025, 2:22pm UTC](https://discourse.itk.org/t/patches-fro-itk-5-4-5/7656 "2025-11-18T14:22:19Z")

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Hi folks, The next patch (bugfix) release, ITK 5.4.5, is coming up. Patches currently staged on the Git release-5.4 branch are: Bradley Lowekamp (1): BUG: Fix setting zero sized CompositeTransforms Dženan…

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## [itk specified file not found error](https://discourse.itk.org/t/itk-specified-file-not-found-error/7665)

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**Author:** [@ali123](https://discourse.itk.org/u/ali123)\
**Replies:** 1\
**Last updated:** [November 17, 2025, 7:12pm UTC](https://discourse.itk.org/t/itk-specified-file-not-found-error/7665 "2025-11-17T19:12:21Z")

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hi i,m realy new to c++, vs and itk i install that with vcpkg and integrate install it i add directory lib and include to project property but i still have problem and get this specified file not found can you p…

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## [Some Dicom format issues](https://discourse.itk.org/t/some-dicom-format-issues/7664)

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**Author:** [@Xoz](https://discourse.itk.org/u/Xoz)\
**Replies:** 3\
**Last updated:** [November 15, 2025, 8:34pm UTC](https://discourse.itk.org/t/some-dicom-format-issues/7664 "2025-11-15T20:34:06Z")

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Hi everyone, I’ve been working with new @itk-wasm/image-io and @itk-wasm/dicom for a while and met some issues with the file format, some of them may be not in plan to be supported, so I would like to know your opinion …

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## [Why I am getting below error while Simple-ITK Build using SuperBuild?](https://discourse.itk.org/t/why-i-am-getting-below-error-while-simple-itk-build-using-superbuild/7661)

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**Author:** [@Shabina](https://discourse.itk.org/u/Shabina)\
**Replies:** 2\
**Last updated:** [November 13, 2025, 7:42am UTC](https://discourse.itk.org/t/why-i-am-getting-below-error-while-simple-itk-build-using-superbuild/7661 "2025-11-13T07:42:25Z")

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\[ 6%\] Built target SuperBuildSimpleITKSourceReal \[ 8%\] Generating uv/bin/uv \[ 26%\] Built target ITK \[ 26%\] Built target SuperBuildSimpleITKSource \[ 43%\] Built target PCRE2 \[ 60%\] Built target Swig \[ 63%\] Creating…

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## [Strange output from RegionOfInterestImageFilter](https://discourse.itk.org/t/strange-output-from-regionofinterestimagefilter/7657)

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**Author:** [@Vasily\_Postnicov](https://discourse.itk.org/u/Vasily_Postnicov)\
**Replies:** 3\
**Last updated:** [November 6, 2025, 3:14pm UTC](https://discourse.itk.org/t/strange-output-from-regionofinterestimagefilter/7657 "2025-11-06T15:14:38Z")

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After applying RegionOfInterestImageFilter to a two-dimensional image like so: #include \<itkImage.h\> #include \<itkRegionOfInterestImageFilter.h\> #include \<itkImageFileReader.h\> #include \<itkImageFileWriter.h\> #include…

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## [ITK 6.0 Beta 1 has been released!](https://discourse.itk.org/t/itk-6-0-beta-1-has-been-released/7651)

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**Author:** [@matt.mccormick](https://discourse.itk.org/u/matt.mccormick)\
**Replies:** 0\
**Last updated:** [October 29, 2025, 9:10pm UTC](https://discourse.itk.org/t/itk-6-0-beta-1-has-been-released/7651 "2025-10-29T21:10:36Z")

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We are excited to announce the first beta release of ITK 6.0! This major version update marks a significant leap forward in the toolkit’s evolution, focusing on code modernization, cleanup, and enhanced performance. As a…

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## [Z stack thickness?](https://discourse.itk.org/t/z-stack-thickness/7648)

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**Author:** [@PART](https://discourse.itk.org/u/PART)\
**Replies:** 2\
**Last updated:** [October 29, 2025, 1:23pm UTC](https://discourse.itk.org/t/z-stack-thickness/7648 "2025-10-29T13:23:19Z")

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Sorry, I’m sure its been asked but I couldn’t find it through the search function but are Z stacks mandatory for multiplexed images registration and if so how does one ensure that you capture the same focal plane with ea…

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## [Would like to compile the ITK without external third-party libraries](https://discourse.itk.org/t/would-like-to-compile-the-itk-without-external-third-party-libraries/7632)

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**Author:** [@Rosie](https://discourse.itk.org/u/Rosie)\
**Replies:** 35\
**Last updated:** [October 24, 2025, 8:14am UTC](https://discourse.itk.org/t/would-like-to-compile-the-itk-without-external-third-party-libraries/7632 "2025-10-24T08:14:22Z")

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Dear developers, I’m attempting to compile all possible ITK target without external third-party libraries. I’m not sure if it will NOT compile all modules that depend on external third-party libraries when I set the ITK…

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## [Overlaying Structures on CT Images in Axial, Coronal, and Sagittal Views](https://discourse.itk.org/t/overlaying-structures-on-ct-images-in-axial-coronal-and-sagittal-views/7647)

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**Author:** [@blue\_sky](https://discourse.itk.org/u/blue_sky)\
**Replies:** 3\
**Last updated:** [October 21, 2025, 1:40pm UTC](https://discourse.itk.org/t/overlaying-structures-on-ct-images-in-axial-coronal-and-sagittal-views/7647 "2025-10-21T13:40:45Z")

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Hello everyone, I am working on displaying CT images in the axial, coronal, and sagittal planes, along with dose maps and RTSTRUCT contours. While the CT and dose images are displayed correctly, I am having trouble over…

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## [The application crashes while generating the NRRD file](https://discourse.itk.org/t/the-application-crashes-while-generating-the-nrrd-file/7646)

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**Author:** [@purushothaman\_u](https://discourse.itk.org/u/purushothaman_u)\
**Replies:** 6\
**Last updated:** [October 17, 2025, 1:32pm UTC](https://discourse.itk.org/t/the-application-crashes-while-generating-the-nrrd-file/7646 "2025-10-17T13:32:19Z")

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In ticket the below ITK ticket an issue has been reported, I have same DICOM files where Bits allocated is 12 for which an exception is supposed to be raised as mentioned in the ticket’s fix is not working instead my …

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## [Inappropriate output for rotating a volume using Euler transform in C++](https://discourse.itk.org/t/inappropriate-output-for-rotating-a-volume-using-euler-transform-in-c/7644)

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**Author:** [@purushothaman\_u](https://discourse.itk.org/u/purushothaman_u)\
**Replies:** 5\
**Last updated:** [October 11, 2025, 9:51am UTC](https://discourse.itk.org/t/inappropriate-output-for-rotating-a-volume-using-euler-transform-in-c/7644 "2025-10-11T09:51:28Z")

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The below code takes the axial volume as input, applies a 90-degree rotation around the z-axis, and writes the output volume to a 90.nrrd file. In 90. When viewing the NRRD file in the ITK-SNAP app, we can see that certa…

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## [Conversion of ITK BSpline to knot-vector representation of splinepy](https://discourse.itk.org/t/conversion-of-itk-bspline-to-knot-vector-representation-of-splinepy/7643)

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**Author:** [@reox](https://discourse.itk.org/u/reox)\
**Replies:** 12\
**Last updated:** [October 9, 2025, 4:17pm UTC](https://discourse.itk.org/t/conversion-of-itk-bspline-to-knot-vector-representation-of-splinepy/7643 "2025-10-09T16:17:45Z")

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Colleagues of mine use a spline library called splinepy. It has some nice features, I wanted to try out, using some ITK BSplineTransforms I have obtained from image registration. However, I wasn’t able to convert them in…

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## [Link what you include?](https://discourse.itk.org/t/link-what-you-include/7639)

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**Author:** [@dzenanz](https://discourse.itk.org/u/dzenanz)\
**Replies:** 0\
**Last updated:** [September 22, 2025, 4:00pm UTC](https://discourse.itk.org/t/link-what-you-include/7639 "2025-09-22T16:00:54Z")

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Has anyone used link-what-you-include tool? Can anyone estimate the effort needed to apply it to ITK? It could be a nice way to keep dependencies between modules and files clean and up to date.

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